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The enzymes DNA methyltransferases catalyze the transfer of methyl groups, derived from SAM, to the CpG islands in the promoter region of a gene, preventing the interaction of this region with the transcriptional machinery and consequently blocking gene expression (Triantaphyllopoulos et al., 2016) ( Figure 1 )

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BACE1 cleavage site selection critical for amyloidogenesis and Alzheimers pathogenesis